Publications

• I.Rajta, R.Huszank, A.Szabo, G.Nagy, S.Szilasi, P.Furjes, E.Holczer, Z.Fekete, G.Jarvas, M.Szigeti, L.Hajba, J.Bodnar, A.Guttman, Tilted pillar array fabrication by the combination of proton beam writing and soft lithography for microfluidic cell capture: 1. design and feasibility, Electrophoresis, 37 (2016) 498-503.
• M.Szigeti, C.Lew, K.Roby, A.Guttman, Fully automated sample preparation with ultrafast N-glycosylation analysis of therapeutic antibodies, JALA, 21 (2016) 281-286.
• M.Kerekgyarto, G.Jarvas, L.Novak, A.Guttman, Activation energy associated with the electromigration of oligosaccharides through viscosity modifier and polymeric additive containing background electrolytes, Electrophoresis, 37 (2016) 573-578.
• A.Szekrenyes, S.S.Park, M.Santos, B.Warren, A.Jones, E.Cosgrave, T.Haxo, S.Pourkaveh, Z.Szabo, Z.Sosic, P.Feng, Cs.Varadi, JB.Falmagne, P.Sejwal, D.Michels, G.Freckleton, M.Hamm, AManuilov, T.Duffy, M.Schwartz, JK.Luo, J.van Dyck, PK.Leung, M.Olajos, B.Moritz, R.Kowle, G.Kai, W.Wenbo, J.Wegstein, A.Guttman, Multi-Site N-Glycan Mapping Study 1: CE-LIF, mAbs, 8 (2016) 56-64.
• J.Bodnar, A.Szekrenyes, M.Szigeti, G.Jarvas, J.Krenkova, F.Foret, A.Guttman, Enzymatic removal of N-glycans by PNGase F coated magnetic microparticles, Electrophoresis, 37 (2016) 1264-1269.
• L.Hajba, A.Guttman, Continuous flow biochemical reactors: biocatalysis, bioconversion and bioanalytical applications utilizing immobilized microfluidic enzyme reactors, J. Flow Chem., 6 (2016) 8-12.
• L.Hajba, A.Guttman, The use of magnetic nanoparticles in cancer theranostic: Towards handheld diagnostic devices, Biotechnology Advances, 34 (2016) 354-361.
• Zs.Kovacs, M.Szarka, M.Szigeti, A.Guttman, Separation window dependent multiple injection (SWDMI) for large scale analysis of therapeutic antibody N-glycans, J. Pharm. Biomed. Analysis, 128 (2016) 367-370.
• B.Donczo, M.Szigeti, Gy.Ostoros, A.Gacs, J.Tovari, A.Guttman, N-glycosylation analysis of formalin fixed paraffin embedded samples by capillary electrophoresis, Electrophoresis, (2016) In Press, DOI: 10.1002/elps.201500446
• M.Szigeti, J.Bodnar, D.Gjerde, Zs.Keresztessy, A.Szekrenyes, A.Guttman, Rapid N-glycan release from glycoproteins by immobilized PNGase F microcolumns, J.Chromatogr. B, (2016) In Press, DOI: 10.1016/j.jchromb.2016.02.006
• G.Jarvas, M.Kerekgyarto, A.Guttman, On the electromigration of charged fluorophore-labeled oligosaccharides in polyethylene oxide solutions. Electrophoresis, (2016) In Press, DOI: 10.1002/elps.201600183
• Zs.Elek, R.Denes, P.Susanne, A.Somogyi, H.Yowanto, J.Luo, M.Souquet, A.Guttman, Zs.Ronai, Multicapillary gel electrophoresis based analysis of genetic variants in the WFS1 gene, Electrophoresis, (2016) In Press, DOI: 10.1002/elps.201600251
• L.Hajba, A.Guttman, Liquid phase separation methods for N-glycosylation analysis of glycoproteins of biomedical and biopharmaceutical interest. A critical review, Anal. Chim. Acta (2016) In Press, DOI: 10.1016/j.aca.2016.08.035

• G.Jarvas, A.Guttman, F.Foret, Numerical modeling in capillary electrophoresis - electrospray mass spectrometry interface design, Mass Spectrometry Reviews, 34 (2015) 558-559.
• G.Jarvas, J.Grymc, F.Foret, A.Guttman, Simulation based design of a microfabricated pneumatic electrospray nebulizer, Electrophoresis, 36 (2015) 386-392.
• Z.Jaczo, E.Pal, R.Denes, A.Somogyi, M.Sasvari-Szekely, A.Guttman, Z.Ronai, Rapid Analysis of Colipase Gene Variants by Multicapillary Electrophoresis, Electrophoresis, 36 (2015) 1237-1243.
• C.Varadi, Z.Hollo, S.Poliska, L.Nagy, Z.Szekanecz, A.Vancsa, K.Palatka, A.Guttman, Combination of IgG N-glycomics and Corresponding Transcriptomics Data to Identify anti TNF? Treatment Responders in Inflammatory Diseases. Electrophoresis, 36 (2015) 1330-1335.
• C.Lew, JL.Gallegos-Perez, B.Fonslow, A.Guttman, Rapid level-3 characterization of therapeutic antibodies by capillary electrophoresis electrospray ionization mass spectrometry (CESI-MS), J. Chrom. Sci., 53 (2015) 443-449.
• A.Szekrenyes, J.Partyka, Cs.Varadi, J.Krenkova, F.Foret, A.Guttman, Sample preparation for N-glycosylation analysis of therapeutic monoclonal antibodies by capillary electrophoresis, Methods in Molecular Biology, 1274 (2015) 183-195.
• G.Jarvas, M.Szigeti, L.Hajba, P.Furjes, A.Guttman, Computational Fluid Dynamics Based Design of a Microfabricated Cell Capture Device, J. Chrom. Sci., 53 (2015) 411-416.
• M.Guttman, Cs.Varadi, K.K.Lee, A.Guttman, Glycoprofiling of HIV gp120 immunogens by capillary electrophoresis and MALDI-MS, Electrophoresis, 36 (2015) 1305-1313.
• Cs.Varadi, A.Guttman, Zs.Hollo, S.Poliska, L.Nagy, Z.Szekanecz, A.Vancsa, K.Palatka, Combination of IgG N-glycomics and corresponding transcriptomics data to identify anti-TNF-alpha treatment responders in rheumatoid arthritis and inflammatory bowel disease, Annals of Rheumatic Diseases ARD (Suppl 2), 74 (2015) 898.
• G.Jarvas, M.Szigeti, A.Guttman, GUcal: An integrated app for glycan structure assignment based on capillary electrophoresis migration times, Electrophoresis, 36 (2015) 3094-3096.
• A.Guttman, M.Kerekgyarto, G.Jarvas, The effect of separation temperature on structure specific glycan migration in capillary electrophoresis, Anal.Chem, 87 (2015) 11630-11634.

• N.Nemeth, M.Kerekgyarto, M.Sasvari-Szekely, Z.Ronai, A.Guttman, Rapid identification of human SNAP-25 transcript variants by a miniaturized capillary electrophoresis system, Electrophoresis, 35 (2014) 379-384.
• T.Tharmalingam, B.Adamczyk, M.Schomberg, A.Szekrenyes, R.M. Kelly, A.Guttman, P.M. Rudd, Comparison of fast and effective separation techniques for the elucidation of IgG N-glycans from selected species, Carbohydrate Research, 389 (2014) 174-175.
• B.Donczo, J.Kerekgyarto, Z.Szurmai, A.Guttman, Glycan microarrays: new angles and novel strategies, Analyst, 139 (2014) 2650-2657.
• L.Hajba, A.Guttman, Circulating tumor cell detection and capture using microfluidics devices, Trends in Analytical Chemistry 59 (2014) 9-16.
• A.Szekely, A.Szekrenyes, M.Kerekgyarto, A.Balogh, J.Kadas, A.Guttman, I.Kurucz, L.Takacs, Multi Capillary SDS-Gel Electrophoresis for the Analysis of Fluorescently Labeled mAb preparations: a high throughput quality control process for the production of QuantiPlasma and PlasmaScan mAb libraries, Electrophoresis 35 (2014) 2155-2162
• Cs.Varadi, C.Lew, A.Guttman, Rapid magnetic bead based sample preparation for automated and high throughput N-glycan analysis of therapeutic antibodies, Anal. Chem., 86 (2014) 5682-5687.
• M.Kerekgyarto, A.Guttman, Toward the generation of an aminonaphthalene trisulfonate labeled N-glycan database for capillary gel electrophoresis analysis of carbohydrates, Electrophoresis, 35 (2014) 2222-2228.
• G.Jarvas, M.Szigeti, L.Hajba, P.Furjes, A.Guttman, Computational Fluid Dynamics Based Design of a Microfabricated Cell Capture Device, J.Chrom.Sci. (2014) In Press
• A.Guttman, Bioseparations, Electrophoresis, 35 (2014) 2067.
• K.Agoston, Gy.Gyemant, L.Kalmar, J.Kerekgyarto, Z.Szurmai, B.Donczo, A.Guttman, Synthesis and MALDI-TOF MS analysis of protected oligosaccharide components of N-glycoproteins, Journal of Carbohydrate Chemistry, 33 (2014) 326-343.

• J.Szalma, K.Boddi, E.Lempel, A.Fsieroslawska, Z.Szabo, R.Harfo, L.Olasz, A.Takatsy, A.Guttman, Proteomic and Scanning Electron Microscopic Analysis of Submandibular Sialoliths, Clinical Oral Investigations, 17 (2013) 1709-1717.
• A.Kovacs, A.Guttman, Medicinal Chemistry Meets Proteomics: Fractionation of the Human Plasma Proteome, Current Medicinal Chemistry 20 (2013) 483-490.
• D.Vanderschaeghe, A.Guttman, N.Callewaert, High-throughput profiling of the serum N-glycome on capillary electrophoresis microfluidics systems, Methods Mol Biol. 919 (2013) 87-96.
• S.Tummala, M.Titus, L.Wilson, C.Wang, C.Ciatto, D.Foster, Z.Szabo, A.Guttman, C.Li, B. Bettencourt, M.Jayaraman, J.Deroot, G.Thill, D.Kocisko, S.Pollard, K.Charisse, S.Kuchimanchi, G.Hinkle, S.Milstein, R.Myers, S.Wu, B.L.Karger, A.Rossomando, RNAi-mediated metabolic engineering: Modulation of fucose content on an anti-CD20 monoclonal antibody using exogenously added siRNA, Biotech. Prog., 29 (2013) 415-424.
• M.Kerekgyarto, N.Nemeth, T.Kerekes, Zs.Ronai, A.Guttman, Ultrafast haplotyping of putative microRNA-binding sites in the WFS1 gene by multiplex polymerase chain reaction and capillary gel electrophoresis, J.Chrom. A., 1286 (2013) 229-234.
• Cs.Varadi, S.Mittermayr, A.Szekrenyes, J.Kadas, L.Takacs, I.Kurucz, A.Guttman, Analysis of haptoglobin N-glycome alterations in inflammatory and malignant lung diseases by capillary electrophoresis, Electrophoresis, 34 (2013) 2287-2294.
• S.Mittermayr, J.Bones, A.Guttman, Unraveling the Glyco-Puzzle: Glycan Structure Identification by Capillary Electrophoresis. Anal.Chem., 85 (2013) 4228-4238.
• M.Kerekgyarto, A.Fekete, Z.Szurmai, J.Kerékgyárt√≥, I.Kurucz, A.Guttman, Neoglycoproteins for carbohydrate specific antibody generation 1: Synthesis, analysis and polyclonal antibody response, Electrophoresis, 34 (2013) 2379-2386.
• A.Guttman, Capillary electrophoresis in the N-glycosylation analysis of biopharmaceuticals, Trends in Analytical Chemistry, 48 (2013) 132-143.
• Y.Wang, M.Santos, A.Guttman, Comparative core fucosylation analysis of some major therapeutic antibody N-glycans by direct infusion electrospray ionization mass spectrometry and capillary electrophoresis - laser induced fluorescence detection. Journal of Separation Science, 36 (2013) 2862-2867.
• A.Szekrenyes, J.Partyka, Cs.Varadi, J.Krenkova, F.Foret, A.Guttman, Sample preparation for N-glycosylation analysis of therapeutic monoclonal antibodies by capillary electrophoresis, Methods in Molecular Biology, (2013) In Press
• A.Kovacs, Z.Patai, A.Guttman, J.Kadas, L.Takacs, I.Kurucz, Fractionation of the human plasma proteome for monoclonal antibody proteomics-based biomarker discovery 2: Antigen identification by dot-blot array screening. Electrophoresis, 34 (2013) 3064-3071.
• A.Guttman, Analytical Glycomics. Electrophoresis, 34 (2013) 2283.
• G.Jarvas, A.Guttman, Modeling of cell sorting and rare cell capture with microfabricated biodevices, Trends in Biotechnology, 31 (2013) 696-703.
• J.Krenkova, A.Szekrenyes, Zs.Keresztessy, F.Foret, A.Guttman, Oriented Immobilization of Peptide-N-glycosidase F on a Monolithic Support for Glycosylation Analysis, J.Chrom. A, 1322 (2013) 54-61.
• M.Szigeti, G.Jarvas, A.Guttman, Design and modeling of microfluidic cell capture devices, Chemicke Listy, 107 (2013) S458-S459.
• B.Barkaszi, A.Guttman, Pathophysiological role of aberrant glycan expression in tumorigenesis and cancer progression, Chemicke Listy, 107 (2013) S343-345.
• B.Donczo L.Kalmar, J.Kerekgyarto, Z.Szurmai, A.Guttman, Combinatorial glycomics 1: Synthesis options, Chemicke Listy, 107 (2013) S353-S354.
• M.Racz, L.Takacs, A.Guttman, J.Lazar, Removal of abundant proteins to enable global proteome analysis of the human plasma: QC methodology development using immunoglobulin and albumin as markers, Chemicke Listy, 107 (2013) S428-S429.
• A.Guttman, Automated N-glycosylation analysis for translational glycomics: quo vadis? Chemicke Listy, 107 (2013) S308.

• A.Szekrényes, U.Roth, A.Székely, I.Kurucz, K.Kowalewski, A.Guttman, High throughput monoclonal antibody analysis by multicapillary SDS gel electrophoresis in conjunction with covalent fluorescent labeling, Anal.Bioanal.Chem 405 (2012) 1485-1494.
• Z.Szabo, J.Bones, A.Guttman, J.Glick, B.L.Karger, Sialic Acid Speciation using Capillary Electrophoresis: Optimization of Analyte Derivatization and Separation, Analytical Chemistry (2012) E-published.
• Z.Szabo, A.Guttman, J.Bones, R.L.Shand, D.Meh and B.L.Karger, Ultrasensitive capillary electrophoretic analysis of potentially immunogenic carbohydrate residues in biologics: 1. Galactose-a-1,3-Galactose Containing Structures, Molecular Pharmaceuticals, (2012) in Press
• M.Ker√©kgy√°rt√≥, T.Kerekes, E.Tsai, V.D.Amirkhanian, A.Guttman, Light emitting diode induced fluorescence (LedIF) detection design for a pen-shape cartridge based single capillary electrophoresis system, Electrophoresis, (2012) in Press
• A.Guttman, Bioanalytical Tools for the Characterization of Biologics and Biosimilars, LC.GC Magazine, 30 (2012) pp 412-421
• S.Mittermayr, A.Guttman, Influence of molecular configuration and conformation on the electromigration of oligosaccharides in narrow bore capillaries, Electrophoresis, 33 (2012) pp 1000-1007.
• B.Mesko, Sz.Poliska, Z.Szekanecz, Sz.Szamosi, J.Podani, Cs.Varadi, A.Guttman, L.Nagy, Peripheral blood gene expression and IgG glycosylation profiles as markers of tocilizumab treatment in rheumatoid arthritis, The Journal of Rheumatology, 39 (2012) pp 916-928.
• R.Garrido-Medina1, A.Puerta1, Z.Rivera-Monroy, M.de Frutos, A.Guttman, J.Carlos Diez-Masa, Analysis of alpha-1-acid glycoprotein isoforms using CE-LIF with fluorescent thiol-derivatization, Electrophoresis, 33 (2012) pp 1113-1119.

• S.Mittermayr, J.Bones, M.Doherty, A.Guttman, P.M.Rudd, Multiplexed analytical glycomics: Rapid and confident IgG N-glycan structural elucidation, Journal of Proteome Research, (2011) In Press
• Z.Szabo, A.Guttman, J.Bones, B.L.Karger, Rapid High Resolution Characterization of Functionally Important Monoclonal Antibody N-Glycans by Capillary Electrophoresis, Analytical Chemistry, (2011) In Press
• Kovacs, E.Sperling, J.Lazar, A.Balogh, J.Kadas, A.Szekrenyes, I.Kurucz, L.Takacs, A.Guttman, Fractionation of the human plasma proteome for monoclonal antibody proteomics based biomarker discovery, Electrophoresis, (2011) In Press
• M.Guergova-Kuras, I.Kurucz, W.Hempel, N.Tardieu, J.Kadas, C.Malderez-Bloes, A.Jullien, Y.Kieffer, M.Hincapie, A.Guttman, E.Csanky, S.Cseh, B.L.Karger. L.Takacs, Discovery of lung cancer biomarkers by profiling the plasma proteome with nascent monoclonal antibody libraries, Molecular and Cellular Proteomics, (2011) In Press
• A.Guttman (Editor), Biomarker discovery and related topics, Electrophoresis, 32 (2011) pp 1915

• J.Bones, S.Mittermayr, N.O'Donoghue, A.Guttman, P.Rudd, Ultra performance liquid chromatographic profiling of serum N-glycans for fast and efficient identification of cancer associated alterations in glycosylation, Anal. Chem., 82 (2010) pp 10208-10215.
• P.Smejkal, A.Szekrenyes, M.Ryvolova, F.Foret, A.Guttman, F.Bek, M.Macka, Chip-based CE for rapid separation of APTS derivatized glycans, Electrophoresis, 31 (2010) pp 3783-3786.
• D.Vanderschaeghe,A.Szekr√©nyes, C.Wenz, M,Gassmann, N,Naik, M,Bynum, H.Yin, J,Delanghe, A.Guttman, N.Callewaert, High-throughput profiling of the serum N-glycome on capillary electrophoresis microfluidics systems: toward clinical implementation of GlycoHepatoTest, Anal. Chem., 82 (2010) pp 7408-7415.
• M.Olajos, A.Szekrenyes, D.T.Gjerde, A.Guttman, Boronic acid - lectin affinity chromatography (BLAC) 3. Temperature dependence of glycoprotein isolation and enrichment, Anal.Bioanal. Chem., 397 (2010) pp 2401-2407.
• O.A Rahman, M.Sasvari-Szekely, A.Szekely, G.Faludi, A.Guttman, Zs.Nemoda, Analysis of a polymorphic microRNA target site in the purinergic receptor P2RX7 gene, Electrophoresis, 31 (2010) pp 1790-195.
• Z.Szabo, A.Guttman, B.L.Karger, Rapid release of N-linked glycans from glycoproteins by pressure cycling technology, Analytical Chemistry, 82 (2010) pp 2588-2593.
• Z.Szabo, A.Guttman, T.Rejtar, B.L.Karger, Improved sample preparation method for glycan analysis of glycoproteins by CE-LIF and CE-MS,, Electrophoresis, 31 (2010) pp 1389-1395.
• V.Vukics, A.Guttman, Structural characterization of flavonoid glycosides by LC-MS/MS, Mass.Spec.Rev., 29 (2010) pp 2806-2815.

• V.Vukics, A.Guttman, Structural characterization of flavonoid glycosides by LC-MS/MS, Mass.Spec.Rev., 10 (2009) E-PUB Dec 30,2008.
• A.Monzo, E.Sperling, A.Guttman, Trypsin immobilization strategies for mass spectrometry based proteomics, Trends in Anal.Chem., 28 (2009) pp 854-864.
• E,Szantai, Z.Elek, A.Guttman, M.Sasvari-Szekely, Candidate gene copy number analysis by PCR and multi capillary electrophoresis, Electrophoresis, 30 (2009) pp 1098-1101.
• Z.Rivera-Monroy, G.K.Bonn, A.Guttman, Fluorescent Isotope Coded Affinity Tag (FCAT) 2: Peptide labeling and affinity capture, Electrophoresis, 30 (2009) pp 1111-1118.
• A.Monzo, T.Rejtar, A.Guttman, Optimization of poly(GMA-co-EDMA) monolithic support for trypsin nanoreactor fabrication, J.Chrom.Science, 47 (2009) pp 467-472.
• S.Spisak, A.Guttman, Protein Microarrays in Biomarker Discovery, Currents in Medicinal Chemistry, 16 (2009) pp 2806-2815.
• S.Mittermayr, T.Chovan, A.Guttman, Two variable semi-empirical and artificial neural network based modeling of peptide mobilities in capillary zone electrophoresis: The effect of temperature and organic modifier concentration, Electrophoresis, 30 (2009) pp 890-896.

•  V.Vukics, B.Hevesi Toth, T.Ringer, K.Ludanyi, A.Kery, G.K.Bonn, A.Guttman, Quantitative and qualitative investigation of the main flavonoids in Heartsease (Viola tricolor L.), J.Chrom.Sci. 46 (2008) 97-101.
•  Z.Rivera, G.Bonn, A.Guttman, Stable isotope coded labeling reagents for quantitative proteomics, Current Organic Chemistry, 12 (2008) 424-440.
•  V.Vukics, A.Kery, G.K.Bonn, A.Guttman, Major flavonoid components of heartsease (Viola tricolor L.) and their antioxidant activities, Anal.Bioanal.Chem., 390 (2008) 1917-25.
•  M.Olajos, P.Hajos, G.K.Bonn, A.Guttman, Sample preparation for the analysis of complex carbohydrates by multi-capillary gel electrophoresis with LED induced fluorescence detection, Anal.Chem, 80 (2008) 4241-4246.
•  S.Mittermayr, M.Olajos, T.Chovan and A.Guttman, Mobility Modeling of Peptides in Capillary Electrophoresis (Review), Trends in Anal.Chem., 27 (2008) 407-417.
•  M.Olajos, T.Chov√°n, S.Mittermayr, T.Kenesei, I.Moln√°r, F.Darvas, A.Guttman, Artificial neural network modeling of pH dependent structure-mobility relationship for capillary zone electrophoresis of tripeptides, J.Liq.Chrom. 31 (2008) 2348 - 2362.
•  V.Vukics, T.Ringer, A.Kery, G.K.Bonn, A.Guttman, Analysis of heartsease (Viola tricolor L.) flavonoid glycosides by micro liquid chromatography coupled to multiple stage mass spectrometry, J.Chromatogr.A. 1206 (2008) 11-20.
•  A.Monzo, M.Olajos, L.De Benedictis, G.K.Bonn, A.Guttman, Boronic acid - lectin affinity chromatography (BLAC) 2. Affinity micropartitioning mediated comparative glycosylation profiling, Anal.Bioanal.Chem. 392 (2008) 195-201.
•  V.Vukics, A.Kery, A.Guttman, Analysis of polar antioxidants in heartsease (Viola tricolor L.) and garden pansy (Viola x wittrockiana Gams.), J.Chrom.Sci. 46 (2008) 823-827.
•  Z.Rivera, G.Bonn, A.Guttman, Synthesis of fluorescent isotope coded affinity tag (FCAT) reagent for quantitative proteomics, Bioorganic Chemistry, 36 (2008) 299-311.